English 
Français 
Español 
Deutsch Neem against HERPES virus
Herpes simplex virus type-1 (HSV-1) causes significant health problems from periodical skin and corneal lesions to encephalitis. We report here that an aqueous extract preparation from the barks of neem plant acts as a potent entry inhibitor against HSV-1 infection into natural target cells. The extract from neem bark (NBE) significantly blocked HSV-1 entry into cells at concentrations ranging from 50 to 100 g/ml. The blocking activity of NBE was observed when the extract was pre-incubated with the virus but not with the target cells suggesting a direct anti-HSV-1 property of the neem bark. Further, virions treated with NBE failed to bind the cells which implicate a role of NBE as an attachment step blocker. Cells treated with NBE also inhibited HSV-1 glycoprotein mediated cell to cell fusion and polykaryocytes formation suggesting an additional role of NBE at the viral fusion step. These finding open a potential new avenue for the development of NBE as a novel anti-herpetic microbicide.
| Nome file: | Neem against HERPES virus.pdf |
| Categoria: | Neem as a viricide |
| Dimensione file: | 1.92 MB |
| Tipo di file: | application/pdf |
- NEEM
- ANTIVIRAL EFFECT
- HERPES
- virus
- HSV-1
- plant antiviral
- herpes simplex type-1
- virus-cell interaction
Documenti correlati
While neem’s immune-boosting properties make it an excellent choice as a preventative, it should NOT be taken if you have contracted the virus. The science gets complicated quickly, but ..
Currently, several problems raised from the frequent application of chemical insecticide for dengue control such as insecticide resistance and
environmental health issues. This fact supporting the need for the ..
Antiviral effect of crude aqueous extracts of Neem leaves and Neem bark (Azadirachta indica) belonging to the family Meliaceae against velogenic Newcastle Disease virus was studied. Maximum non- toxic ..
Dengue is endemic in more than 100 countries and it is estimated that annually above 390 million in-fections occur globally. During the period between 1996e2015, a massive increase of ..
Now an assistant professor at Kean University in New Jersey, Arora is delving into understanding the curative properties of the neem tree in fighting the virus that causes AIDS. ..
