Therapeutics Role of Neem in Diseases Prevention and Treatement

Neem (Azadirachta indica) is a member of the Meliaceae family and its role as health-promoting effect is attributed because it
is rich source of antioxidant. It has been widely used in Chinese, Ayurvedic, and Unani medicines worldwide especially in Indian
Subcontinent in the treatment and prevention of various diseases. Earlier finding confirmed that neem and its constituents play role
in the scavenging of free radical generation and prevention of disease pathogenesis.The studies based on animal model established
that neem and its chief constituents play pivotal role in anticancer management through the modulation of various molecular
pathways including p53, pTEN, NF-?B, PI3K/Akt, Bcl-2, and VEGF. It is considered as safe medicinal plants and modulates
the numerous biological processes without any adverse effect. In this review, I summarize the role of Azadirachta indica in the
prevention and treatment of diseases via the regulation of various biological and physiological pathways.