Neem against HERPES virus
Herpes simplex virus type-1 (HSV-1) causes significant health problems from periodical skin and corneal lesions to encephalitis. We report here that an aqueous extract preparation from the barks of neem plant acts as a potent entry inhibitor against HSV-1 infection into natural target cells. The extract from neem bark (NBE) significantly blocked HSV-1 entry into cells at concentrations ranging from 50 to 100 g/ml. The blocking activity of NBE was observed when the extract was pre-incubated with the virus but not with the target cells suggesting a direct anti-HSV-1 property of the neem bark. Further, virions treated with NBE failed to bind the cells which implicate a role of NBE as an attachment step blocker. Cells treated with NBE also inhibited HSV-1 glycoprotein mediated cell to cell fusion and polykaryocytes formation suggesting an additional role of NBE at the viral fusion step. These finding open a potential new avenue for the development of NBE as a novel anti-herpetic microbicide.
| Nombre de archivo: | Neem against HERPES virus.pdf |
| Categoría: | Neem as a viricide |
| Tamaño del archivo: | 1.92 MB |
| Tipo de archivo: | application/pdf |
- NEEM
- ANTIVIRAL EFFECT
- HERPES
- virus
- HSV-1
- plant antiviral
- herpes simplex type-1
- virus-cell interaction
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